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Brittany Deane recalled that she and her sister spotted the Salyers twins at one of the festival's welcoming events.

"We were sitting on the bleachers and I saw just these two amazingly handsome young men that looked to be about our age," she recalled to ABC News, "and they were walking across the gym floor below."

Her sister Briana Deane recalls that her sister grabbed her by the wrist, "which we always do when we get excited about something," she said. And after a few moments, she too had spotted the brothers.

"They were stunning," Briana Deane said of her now-fiance and his twin brother.

Woman who thinks she's taking a photo gets picture-perfect proposal
Preschoolers help pull off precious marriage proposal for their teacher

Sadly, the twin siblings didn't cross paths until the last day of the festival for it's closing night party. "They were there at the end of the hall," Briana Deane said. "They smiled at us and we all started talking."

The Salyers twins sent the Deane twins a message via Facebook saying they couldn't wait to bump into them next year at the festival. But instead, the sisters asked, "Why wait?" The brothers then made a road trip out of it -- driving from their previous home in Clinton, Tennessee to visit the sisters in Virginia. After an amazing trip, the brothers said they knew immediately they'd propose one day.

"You know when you know," Jeremy Salyers said. "We’ve always known our whole life if we were going to be married that it was going to be with twins."

The brothers, who now live in Hagerstown, Maryland, planned a proposal at the same location as their first date -- Twin Lakes State Park in Virginia. They told the sisters the wedding venue on-site wanted to feature the four in a commercial, so they all arrived in matching blue gowns and matching blue ties.

What the Deane sisters didn't expect was for the Salyers brothers to drop down on one knee at the same time. It made it even more special for all of the pairs.

"We have done so much in life together. We’ve gone through ... having twin loves of our lives and to accept their marriage proposal at the same time made it that much more special," Brittany Deane said.

Josh Salyers added, "We’ve always felt blessed to have each other and now we have two other twins who are just like us...but they also add their own contributions that we couldn’t have. Together we can accomplish anything."

The couples now plan to have a double wedding this August at the Twins Days Festival in Ohio. And yes, if you're wondering, the brides will be in identical wedding dresses.

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Zuckerberg cited “a responsibility to make sure our services aren’t just fun to use, but also good for people’s well-being” as justification for the change, admitting that businesses will have to work harder than ever to gain their customers’ attention on the platform.

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The effect of the fluoroquinolones on insulin secretion has been studied, and the results suggest that these antibiotics cause hypoglycemia by increasing insulin release via blockade of adenosine triphosphate-sensitive K + channels in the β cells of the pancreas [ 30 , 31 ]. This effect may not be clinically significant in all patients because of physiologic mechanisms that regulate blood glucose levels. In contrast, the mechanism of hyperglycemia is not clear. One contributing factor may be overexposure (eg, failure to adjust the dose in patients with renal insufficiency) [ 32 ]. The results of our study and of others [ 12 , 15 , 16 , 20 , 21 ], as well as this potentially common mechanism for hypoglycemia, suggest the need for caution when using certain fluoroquinolones, because the odds of hypo- and hyperglycemia appear to vary among the agents [ 33 ]. This is not unusual; differences in risk have been reported for other adverse effects with this class of antibiotics [ 34 ].

Our results are generally consistent with those presented in the literature. In a retrospective medical-record review of dysglycemia in hospitalized patients receiving gatifloxacin, levofloxacin, ciprofloxacin, or ceftriaxone, dysglycemic events were more likely to occur in patients receiving gatifloxacin (relative risk, 3.29; 95% CI, 2.33–4.65) or levofloxacin (relative risk, 1.55; 95% CI, 1.29–1.88) versus ceftriaxone [ 20 ]. There was no difference in the risk of dysglycemia between gatifloxacin and levofloxacin (P=.8). However, hypo- and hyperglycemic events were combined in this study. None of the patients who received ciprofloxacin experienced a dysglycemic event. In a nested case-control study of hospitalized patients who received gatifloxacin or levofloxacin, the odds of hypoglycemia were greater with gatifloxacin versus levofloxacin (OR, 2.81; 95% CI, 1.02–7.70) [ 12 ]. No comparator antibiotic was included in the study, so the possibility of a fluoroquinolone class effect could not be assessed. In another study of elderly inpatients who received gatifloxacin or levofloxacin, gatifloxacin was independently associated with hypoglycemia (OR, 2.4; 95% CI, 1.1–5.6) and hyperglycemia (OR, 2.5; 95% CI, 1.6–3.9) versus levofloxacin [ 21 ]. Again, a nonfluoroquinolone antibiotic was not included in the study.

Dysglycemic events have also been evaluated among outpatients receiving fluoroquinolones. In a smaller, regional database review of the effect of fluoroquinolones on glucose metabolism among veterans with an outpatient or discharge prescription for any of these antibiotics, Coblio et al [ 15 ] state that gatifloxacin was no more likely to cause hypo- or hyperglycemia than levofloxacin or ciprofloxacin among patients with or without diabetes, but they did not report statistical significance. In addition, no comparator was included, so the possibility of a class effect could not be assessed. In a nested case-control study of outpatient fluoroquinolone therapy and dysglycemia requiring hospitalization, gatifloxacin (OR, 4.3; 95% CI, 2.9–6.3) and levofloxacin (OR, 1.5; 95% CI, 1.2–2.0) were associated with an increased risk of hypoglycemia versus macrolides, but ciprofloxacin and moxifloxacin were not [ 16 ]. Compared with macrolide antibiotics, only gatifloxacin was associated with an increased risk of hyperglycemia (OR, 16.7; 95% CI, 10.4–26.8). The authors' findings were similar when their results were stratified by the presence or absence of diabetes. In our study, the small number of events in patients without diabetes (despite our large sample) combined with low ORs and lack of statistical significance suggest that clinical focus regarding risk with the remaining fluoroquinolones should be on those with diabetes.

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